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 | Seeking Recycling technologies for biodegradable films |
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We are looking for solutions to convert bio-based packaging back to starting materials or other high-value added chemicals (no fuels). |
| | Seeking natural colors for foods and beverages |
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PepsiCo is evaluating different natural color ingredients and technologies to replace Yellow #5, Yellow #6, Red #40, and Blue #1 for multiple food and beverage brands in order to address consumer demand. Specific challenges are in the Red #40 (food) and Blue #1 (food & beverage) replacers. |
 | Seeking existing market solutions targeted towards crawling insects |
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The issue of crawling insects in homes has been an ongoing issue. The popular types of crawling insects causing problems have been ants and cockroaches. The search will focus on existing market solutions targeted towards crawling insects such as ants and cockroaches (other types of crawling insects are in scope i.e., bed bugs). |
 | NanoMEDIC gene editing delivery system |
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Background Gene therapy holds great potential for the treatment of genetic diseases. However, delivery to specific tissues is still a major bottleneck. Although AAV-delivered CRISPR-Cas9 editing is being developed for multiple diseases, its therapeutic translation is hindered by the limited packaging capacity of viral particles and possible immune response to them. Moreover, AAV transgenes tend to be expressed for an extended period of time, which increases off-target mutagenesis risk. Extracellular vesicles (EV) is another option and, when combined with ribonucleoprotein (RNP) delivery of CRISPR-Cas9, reduces off-target effects. The structural polyprotein Gag is typically used to package cargo into EVs, which nevertheless limits the EV packaging capacity. The present invention is an all-in-one EV delivery system termed NanoMEDIC (nanomembrane-derived extracellular vesicles for the delivery of macromolecular cargo). It is a transient EV-based CRISPR-Cas9 editing delivery system which ensures efficient genome editing in various cell types. |
 | System for improving accessibility in learning platforms by using push buttons, for people with motor disabilities. |
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Researchers from the Automation Department of the University of Alcalá present a system that improves the accessibility to learning platforms, through an automatic or manual scanning controlled by push buttons, very useful in the education sector, specifically for people with motor disabilities. The researchers are looking for companies in electronic engineering, telecommunications, audiovisual technology and computing, companies that develop learning platforms, companies that develop computer peripherals and adapted devices, academies or training centers, interested in reaching collaboration agreements, licensing agreements or commercial agreements with technical assistance. |
 | Circular RNA biomarkers for heart failure diagnostics |
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Circular RNAs are a class of noncoding RNAs covalently closed by a back spicing event, making them protected from degradation by exonuclease. They are tissue- and disease-specific and are detectable in the blood. These properties confer circRNAs with valuable potential as disease biomarkers for diagnostic and therapeutic purposes. The Cardiovascular Research team of the Luxembourg Institute of Health leaded by Dr Yvan Devaux has discovered and patented hundreds of circRNAs detectable in the blood and associated with cardiovascular conditions such as heart failure. Heart failure affects more than half of the population over 65 and represents an enormous financial burden to the society. Circular RNAs can be measured in a highly specific manner using sequencing, methods based on probe hybridization, or quantitative PCR with divergent primers. They have potential to be used in diagnostics tests, companion diagnostics or, being involved in disease development and progression, as therapeutic targets. |
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